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| deMix - Decoding deuterated Distributions from heterogeneous protein states via HDX-MS ( Software download ) |
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| deMix deals directly with the deuterated isotopic distributions, but not considering their centroid masses and is designed to be robust over random noises. In addition, unlike the existing approaches that can only determine a single state from an isotopic distribution, deMix can also detect a bimodal deuterated distribution, arising from EX1 behavior or heterogeneous peptides in conformational isomer proteins. Furthermore, deMix comes with visualization software to facilitate validation and representation of the analysis results. |
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 Publication
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deMix: Decoding Deuterated Distributions from Heterogeneous Protein States via HDX-MS.
Seungjin Na, Jae-Jin Lee, Jong Wha J. Joo, Kong-Joo Lee and Eunok Paek.
Scientific Reports, 2019, 9(1):3176. [ PMID: 30816214 ] |
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