This site features
MODPlus
(advanced version of MODi)
, a powerful modification search engine that uses mass spectrometry data to identify protein
modifications. MODPlus facilitates cutting-edge proteomics research by extensively searching
through hundreds of potential modifications efficiently. Among the existing search tools, MODPlus
can take the most number of modifications as its search parameter.
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Special search engine for disulfide linkage analysis, DBond.
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Certain post-translational modifications involve more than one peptide
and thus cannot be easily searched by conventional modification search algorithms. We provide
specialized software, DBond that can analyze intact disulfide linkage between two peptides.
Disulfide linkages not only contribute to the stability of a protein's structure, but it is
known to regulate mediation of various signaling pathways in a cell. It is of particular
interest to biopharmaceutical industry as disulfide bridge characterization is an important part
of acceptance criteria for biological products.
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A Database of Structurally Validated Protein Modifications, StrucPTM.
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StrucPTM is a comprehensive structural database that systematically extracts
and contextualizes post-translational modification (PTM) sites within experimentally determined protein
structures. By directly validating PTMs from PDB mmCIF files using atom-level composition rules and comparing
homologous structures, StrucPTM provides a critical foundation for analyzing PTM-induced conformational variations.
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